Dr Ghavamzadeh performed the first bone marrow transplant in 1990 for the treatment of leukemia. Data suggests that more than 8,000 transplants have been performed in Iran. However, the first stem cell injection for the treatment of non-blood diseases was performed in 2004 by researchers at the Royan Research Institute to repair heart attacks caused by stroke. Furthermore, researchers at the Royan Research Institute used stem cells to repair corneal lesions in 2005. Research in cell therapy for vitiligo patients began in 2008.
Research is currently underway at Royan Research Institute to treat more than 40 different diseases in the fields of skin, orthopedics, heart, neurology, kidney, eye and reproduction, and women. There are currently more than 27,000 clinical trials of cell therapy in the world, most of them in the United States and then in Europe and China. In the Middle East region, there are 931 studies about stem cell therapy of which 100 are studied in Iran.